What is the connection between IGF-1 and HGH?


IGF-1 (insulin-like growth factor-1) and HGH (human growth hormone) are hormones that play complicated roles in aging. The relationship between the two is that GH is secreted by your pituitary gland, which stimulates IGF-1 production by action on your liver where it’s made. This close relationship between HGH and IGF-1 causes many to fuse the two together. IGF-1 actually mediates the growth-promoting effects most of us associate with HGH because it stimulates the proliferation, growth, and survival of cells. HGH possesses some extra advantages (general rejuvenation of the body, the skin becomes smoother, the hair grows quicker, and a lot more) which are absent with IGF-1. IGF-1 is used where more performance driven goals like maximizing growth and maintaining muscle and neurons are desired. IGF-1 has immediate effects, whereas HGH has a longer loading period.
Facts about IGF-1 and HGH?
IGF-1 plays a key role in promoting and maintaining your muscle mass and neuro function Growth Hormone.
A 30-60 minute sauna session increases HGH by 140 percent.
A person can adapt to the strenuous activity and not experience a decrease in HGH over time.
Exercise can encourage growth hormone release and thus IGF-1.
Exercised-induced neurogenesis is mediated through IGF-1 induced during exercise.
IGF-1 acts as a neurotrophic factor in the brain, contributing to the growth of new brain cells and survival of existing neurons.
IGF-1 is release in response to HGH is anabolic promoting growth and repairing skeletal muscle.
The process of HGH release in response to exercise is proportional to how strenuous the activity is.
Types of IGF-1 and HGH
IGF-1 is a compounded medication and is made by compounding pharmacies. There are two forms of IGF-1, a long acting version and a short acting version. HGH is a commercially made medication with different brand names (e.g. norditropin, omnitrope, genotropipn, nutropin). Both hormones are available as a subcutaneous injection.
The safest course for consumers interested in Human Growth Hormone Therapy is to consult a physician who prescribes HGH only for FDA approved uses and for adults with growth hormone deficiency. Guidelines further state that adult growth hormone deficiency syndrome (AGHD or GHD) must be confirmed through provocative testing.
The Glucagon stimulation test is currently our provocative test of choice for the diagnosis of GHD. It is readily available and simple to perform. The only contraindications are in the malnourished or those who have not eaten in the previous 48 hours. The entire test takes a total of 2-3 hours from glucagon injection to final blood draw, with GH levels being measured at 0, 90, 135, and 180 minutes. An increase in growth hormone above a certain level due to the glucagon injection is considered to be indicative of pituitary sufficiency and NOT consistent with a diagnosis of adult-onset growth hormone deficiency.
Patients who are not candidates for HGH but are interested in other GH optimization therapies have options such as: Sermorelin, Ipamorelin, Tesamorelin, CJC 1295, GHRP-2, GHRP-6 and IGF-1. These therapies do not require a stimulation test. In this a case, a regular blood test which also includes an IGF-1 score is needed first to determine treatment options.

Leave a Reply

Your email address will not be published. Required fields are marked *